Title: Rapid Acquisition of Gigapascal-High-Pressure Resistance by Escherichia coli
Authors: Vanlint, Dietrich
Mitchell, Rachael
Bailey, Edward
Meersman, Filip
McMillan, Paul F
Michiels, Chris
Aertsen, Abram # ×
Issue Date: Jan-2011
Series Title: mBio vol:2 issue:1
Article number: e00130-10
Abstract: Pressure and temperature are important environmental variables that influence living systems. However, while they vary over a considerable range on Earth and other planets, it has hardly been addressed how straightforwardly and to what extent cellular life can acquire resistance to extremes of these parameters within a defined genomic context and a limited number of generations. Nevertheless, this is a very pertinent question with respect to the penetration of life in allegedly inhospitable environments. In this study, directed evolution was used to reveal the potential of the nonsporulating and mesophilic model bacterium Escherichia coli to develop the ability to survive exposure to high temperature or pressure. While heat resistance could only marginally be increased, our data show that piezoresistance could readily and reproducibly be extended into the GPa range, thereby greatly exceeding the currently recognized maximum for growth or survival.
ISSN: 2150-7511
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Centre for Food and Microbial Technology
× corresponding author
# (joint) last author

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