Title: T-lymphoid extramedullary (lymphadenopathic) blast crisis in CML
Authors: Van Dorpe, Jo ×
Van Damme, S
Jacobs, V
Van den Berghe, Herman
Criel, A
Michielssen, P
Louwagie, A #
Issue Date: 1995
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:50 issue:2 pages:121-5
Abstract: T-cells are only rarely involved in chronic myeloid leukemia. We report an unusual case of T-lymphoid extramedullary (lymphadenopathic) blast crisis in a 66-year-old patient with Philadelphia positive chronic myeloid leukemia. The lymph node morphological picture resembled that of a peripheral T-cell lymphoma. Immunohistochemical stainings showed most lymph node blasts to have T-phenotype (positivity for CD-2, CD-3 and CD-5). Flow cytometric phenotyping confirmed T-phenotype, with positivity for CD-7, CD-38 and TdT. Cytogenetic analysis of lymph node cells revealed Philadelphia chromosome with an additional chromosomal abnormality (add(6p)). The BCR-gene rearrangement in the lymph node blasts was identical to that in the bone marrow. This case adds to the growing evidence that CML may be a disorder of the common stem cell from which T-, B- and myeloid progenitors originate.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Medical Clerkships Centers
× corresponding author
# (joint) last author

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