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Title: Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis
Authors: Gijbels, K ×
Van Damme, Jozef
Proost, Paul
Put, W
Carton, Herwig
Billiau, Alfons #
Issue Date: Jan-1990
Series Title: European Journal of Immunology vol:20 issue:1 pages:233-5
Abstract: Interleukin 6 (IL6) is one of the major inflammation-associated cytokines. Elevated serum or tissue levels of IL6 have been reported to occur in several human diseases, including infections of the central nervous system (CNS), but not in non-infectious CNS inflammation, e.g. multiple sclerosis. While studying experimental autoimmune encephalomyelitis (EAE) as an animal model for autoimmune inflammation of the CNS, we found increased IL6 levels in the CNS of mice suffering from a lethal form of the disease. IL6 levels in the spleens and sera were not significantly increased. These findings are indicative of local production of IL6 in the CNS during EAE, and represent the first demonstration of IL6 production in non-infectious CNS inflammatory disease.
ISSN: 0014-2980
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
Research Group Experimental Neurology
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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