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Title: Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology
Authors: Gómez-Barrena, Enrique ×
Rosset, Philippe
Müller, Ingo
Giordano, Rosaria
Bunu, Carmen
Layrolle, Pierre
Konttinen, Yrjö T
Luyten, Frank #
Issue Date: Jun-2011
Publisher: Wiley-Blackwell Publishing Ltd.
Series Title: Journal of Cellular and Molecular Medicine vol:15 issue:6 pages:1266-1286
Article number: 10.1111/j.1582-4934.2011.01265.x
Abstract: Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue. Cell based therapies are promising new therapeutic approaches in regenerative medicine. By using mesenchymal stem cells (MSC), good results have been reported for bone engineering in a number of clinical studies, most of them investigator initiated trials with limited scope with respect to controls and outcome. With the implementation of a new regulatory framework for advanced therapeutic medicinal products (ATMP), the stage is set to improve both the characterization of the cells and combination products, and pave the way for improved controlled and well designed clinical trials. The incorporation of more personalized medicine approaches, including the use of biomarkers to identify the proper patients and the responders to treatment, will be contributing to progress in the field. Both translational and clinical research will move the boundaries in the field of regenerative medicine, and a coordinated effort will provide the clinical breakthroughs, particularly in the many applications of bone engineering.
URI: 
ISSN: 1582-4934
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Rheumatology Section (-)
× corresponding author
# (joint) last author

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