Title: "Viologen" dendrimers as antiviral agents: the effect of charge number and distance
Authors: Asaftei, Simona ×
De Clercq, Erik #
Issue Date: May-2010
Publisher: ACS Publications
Series Title: Journal of Medicinal Chemistry vol:53 issue:9 pages:3480-3488
Abstract: A series of "viologen" derivatives (4,4'-bipyridinium salts) carrying between 1 and 90 charges per molecule have been prepared and investigated for their activity against human immunodeficiency virus (HIV), herpes simplex virus (HSV), vesicular stomatitis, Punta Toro virus, Sindbis virus, Reovirus, and respiratory syncytial viruses. In general, most of the compounds showed good activities against HIV-1 (strain III(B)). In particular, compound 36 exhibited the highest in vitro activity and selectivity index against HIV-1 (strain III(B)) (EC(50) = 0.26 +/- 0.08 microM, SI = 75.7) in MT-4 cells. The results imply that the antiviral activity requires an optimal number and distance of the positive charges.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2010069.pdf Published 1469KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science