Title: Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates
Authors: Kulik, Katarzyna ×
Radzikowska, Ewa
Kaczmarek, Renata
Baraniak, Janina
Stec, Wojciech J
De Clercq, Erik
Balzarini, Jan
Pannecouque, Christophe #
Issue Date: 2011
Publisher: Blackwell Scientific Publications
Series Title: Antiviral Chemistry & Chemotherapy vol:21 issue:3 pages:143-50
Abstract: Pyrimidine nucleoside analogues represent an established class of clinically useful antiviral agents. Once inside the cell, they are activated by a series of intracellular phosphorylation steps to produce 5´-triphosphate derivatives. In many cases, nucleoside analogues are poor substrates for the cellular kinases needed for their activation. It is clear that intracellular introduction of nucleoside analogues as phosphorylated metabolites (so called pronucleotides) could circumvent difficulties associated with the use of non-phosphorylated nucleoside analogues.
ISSN: 0956-3202
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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