Title: Synthesis of pyridodiazepinediones by using the Ugi multicomponent reaction
Authors: Van den Bogaert, An
Nelissen, Jo
Ovaere, Margriet
Van Meervelt, Luc
Compernolle, Frans
De Borggraeve, Wim # ×
Issue Date: Oct-2010
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:28 pages:5397-5401
Abstract: Benzodiazepines show a broad spectrum of biological activities. In an ongoing effort to extend molecular diversity in this type of systems, we developed a strategy for synthesizing3,4-dihydro-1H-pyrido[2,3-e][1,4]diazepine-2,5-dione compounds starting from 2-hydroxynicotinic acid and by using an Ugi reaction as a key step in the synthesis. We opted to use 2-isocyanophenyl benzoate instead of Armstrong's convertible isocyanide in this multicomponent reaction.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Chemistry - miscellaneous
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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