I-123/125-labelled 2-iodo-L-phenylalanine and 2-iodo-D-phenylalanine: comparative uptake in various tumour types and biodistribution in mice
Kersemans, Veerle × Cornelissen, Bart Kersemans, Ken Bauwens, Matthias Dierckx, Rudi A De Spiegeleer, Bart Mertens, John Slegers, Guido #
European journal of nuclear medicine and molecular imaging vol:33 issue:8 pages:919-927
Purpose: In vitro in the R1M cell model and in vivo in the R1M tumour-bearing athymic model, both [I-123]- 2- iodo-L-phenylalanine and [I-123]-2-iodo-D-phenylalanine have shown promising results as tumour diagnostic agents for SPECT. In order to compare these two amino acid analogues and to examine whether the observed characteristics could be generalised, both isomers were evaluated in various tumour models.