Title: Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs
Authors: Chen, Yong-Jun
Gao, Ling-Jie
Murad, Ibrahim
Verstuyf, Annemieke
Verlinden, Lieve
Verboven, Christel
Bouillon, Roger
Viterbo, Davide
Milanesio, Marco
Van Haver, Dirk
Vandewalle, Maurits
De Clercq, Pierre J # ×
Issue Date: Jan-2003
Publisher: Royal Society of Chemistry
Series Title: Organic & biomolecular chemistry vol:1 issue:2 pages:257-267
Abstract: A novel series of analogs of 1,25-dihydroxyvitamin D3, the hormonally active metabolite of vitamin D3, characterised by the presence of a trans-fused decalin CD-ring system, possesses surprising biological activities in combination with specific structural modifications in the flexible parts of the molecule, when compared with the natural hydrindane derivatives. (1) A large difference in biological activity is observed between the 20-epimeric trans-decalin analogs that follows a pattern opposite to what is usually observed for the natural ring size. (2) Several trans-decalin analogs that are modified in the seco-B-ring region, including previtamin derivatives, possess a pronounced vitamin D-like activity, whereas the corresponding hydrindane derivatives are inactive. The molecular origin of this behavior is still under study.
ISSN: 1477-0520
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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