Title: Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials
Authors: Zwierzina, Heinz
Bardelli, Alberto
Ciardiello, Fortunato
Gariboldi, Manuela
Håkansson, Leif
Lambrechts, Diether
Lind, Guro E
Loeffler-Ragg, Judith
Schmoll, Hans
Siena, Salvatore
Tabernero, Josep
Van Cutsem, Eric # ×
Issue Date: Dec-2010
Publisher: Current Drugs
Series Title: Current Opinion in Molecular Therapeutics vol:12 issue:6 pages:703-11
Abstract: Few breakthroughs in preclinical research have translated into meaningful benefits, either in clinical terms or quality of life, for patients with advanced colorectal cancer, despite important preclinical discoveries regarding aberrant biological pathways associated with disease development and progression. The many reasons for the slow progress are diverse, ranging from the failure to codevelop biomarkers and targeted therapies, the regulatory burdens imposed on academic investigators, and the failure to collect serial tumor biopsies during clinical trials. This review discusses promising translational research that could help reduce the disparity between preclinical discovery and patient benefit, and advocate the concentration of efforts and resources on the most promising therapeutic targets in colorectal cancer, such as EGFR, VEGF and Fcγ receptor.
ISSN: 1464-8431
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Translational Research in GastroIntestinal Disorders
Clinical Digestive Oncology (+)
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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