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Title: Determination of a platelet activating factor antagonist (CV-3988): methodology and clinical application
Authors: Verbesselt, RenĂ© ×
Tjandra-Maga, Tikma Budya
De Schepper, P J
Itakura, K
Sugiro, T #
Issue Date: Apr-1990
Series Title: Journal of Chromatography vol:526 issue:2 pages:515-24
Abstract: A high-performance liquid chromatographic method was developed for determination of the platelet activating factor antagonist CV-3988 in human plasma and urine. After development of a column extraction procedure without an internal standard, a more satisfactory organic extraction procedure was set up with amiodarone as internal standard. Linearity of the calibration curves was found in the range 0.0625-10 micrograms/ml CV-3988. Reproducibility was higher than 10% for the column extraction and lower than 10% for the organic extraction procedure. Recovery of CV-3988 from plasma averaged 81.7% for the column procedure and 40% for the organic extraction. Urine samples could be extracted only by the organic extraction procedure. The organic extraction procedure was applied to the determination of CV-3988 in plasma and urine samples after intravenous administration to normal volunteers.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Clinical Pharmacology Centre (-)
× corresponding author
# (joint) last author

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