Title: Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
Authors: Maurer-Stroh, Sebastian ×
Debulpaep, Maja
Kuemmerer, Nico
de la Paz, Manuela Lopez
Martins, Ivo Cristiano
Reumers, Joke
Morris, Kyle L
Copland, Alastair
Serpell, Louise
Serrano, Luis
Schymkowitz, Joost
Rousseau, Frederic #
Issue Date: Mar-2010
Publisher: Nature Pub. Group
Series Title: Nature Methods vol:7 issue:3 pages:237-U109
Abstract: Protein aggregation results in beta-sheet-like assemblies that adopt either a variety of amorphous morphologies or ordered amyloid-like structures. These differences in structure also reflect biological differences; amyloid and amorphous beta-sheet aggregates have different chaperone affinities, accumulate in different cellular locations and are degraded by different mechanisms. Further, amyloid function depends entirely on a high intrinsic degree of order. Here we experimentally explored the sequence space of amyloid hexapeptides and used the derived data to build Waltz, a web-based tool that uses a position-specific scoring matrix to determine amyloid-forming sequences. Waltz allows users to identify and better distinguish between amyloid sequences and amorphous beta-sheet aggregates and allowed us to identify amyloid-forming regions in functional amyloids.
ISSN: 1548-7091
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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