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Title: Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes
Authors: Landuyt, W ×
Theys, Jan
Nuyts, Sandra
Drijkoningen, Maria
Fowler, J
Reijnders, A
Liekens, Sandra
Neyts, Johan
de Bruijn, Ernst
Anné, Jozef
Lambin, Philippe #
Issue Date: Jan-2001
Series Title: Cancer investigation vol:19 issue:1 pages:35-40
Abstract: Potential anticancer therapy with the fumagillin analog TNP-470 was investigated in the present project using subcutaneously growing rhabdomyosarcomas in rats. Specifically, influences of different tumor sizes at the start of treatment as well as dose/schedules were evaluated with this angiogenesis inhibitor. The results show a significant (p = < or = 0.01) reduction of the growth rate, even for relatively large-sized (> 7 cm3) tumors, when 50 mg/kg TNP-470 was used every other day for up to 3 or 5 injections. With 30 mg/kg TNP-470 injections, effects were seen only with tumors measuring < 7 cm3. The histologic examinations demonstrate an increase in necrosis, both in the center and in the peripheral part of TNP-470-treated tumors. Overall, both tumor volume and drug dose determine treatment outcome with the rat rhabdomyosarcoma. The results suggest that angiogenesis inhibitors could represent a valid component in the treatment of progressive tumor growth, also of large tumors as often encountered in clinics. The antivasculature therapy might also improve hypoxia/necrosis-related therapeutic approaches.
ISSN: 0735-7907
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
Laboratory of Virology and Chemotherapy (Rega Institute)
Laboratory of Molecular Bacteriology (Rega Institute)
Department of Oncology - miscellaneous
Interdepartmental Platform Hospital Care
× corresponding author
# (joint) last author

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