Title: Integrating nuclear receptor mobility in models of gene regulation
Authors: Gelman, Laurent ×
Feige, Jerome N
Tudor, Cicerone
Engelborghs, Yves
Wahli, Walter
Desvergne, Beatrice #
Issue Date: 2006
Publisher: Nuclear Receptor Signaling Atlas
Series Title: Nuclear Receptor Signaling vol:4 pages:e010
Abstract: The mode of action of nuclear receptors in living cells is an actively investigated field but much remains hypothetical due to the lack, until recently, of methods allowing the assessment of molecular mechanisms in vivo. However, these last years, the development of fluorescence microscopy methods has allowed initiating the dissection of the molecular mechanisms underlying gene regulation by nuclear receptors directly in living cells or organisms. Following our analyses on peroxisome proliferator activated receptors (PPARs) in living cells, we discuss here the different models arising from the use of these tools, that attempt to link mobility, DNA binding or chromatin interaction, and transcriptional activity.
ISSN: 1550-7629
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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