Title: Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
Authors: Van Calster, Ben ×
Vanden Bempt, Isabelle
Drijkoningen, Maria
Pochet, Nathalie
Cheng, Jiqiu
Van Huffel, Sabine
Hendrickx, Wouter
Decock, Julie
Huang, HJ
Leunen, Karin
Amant, Frédéric
Berteloot, Patrick
Paridaens, Robert
Wildiers, Hans
Van Limbergen, Erik
Weltens, Caroline
Timmerman, Dirk
Van Gorp, T
Smeets, Ann
Van den Bogaert, Walter
Vergote, Ignace
Christiaens, Marie-Rose
Neven, Patrick #
Issue Date: Jan-2009
Publisher: M. Nijhoff
Series Title: Breast Cancer Research and Treatment vol:113 issue:1 pages:181-187
Abstract: AIMS: To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status.

METHODS: 2227 recently operated cases in one centre were retrieved from the Multidisciplinary Breast Centre database and stratified according to their combined immunohistochemical (IHC) expression of ER/PR/HER-2 status. An equivocal HER-2 status was further analysed by Fluorescence in situ Hybridisation (FISH). The following 6 groups were considered: ER(-)PR(-)HER-2(-) (NNN; triple negative), ER(-)PR(-)HER-2(+) (NNP), ER(+)PR(-)HER-2(-) (PNN), ER(+)PR(-)HER-2(+) (PNP), ER(+)PR(+)HER-2(- )(PPN), ER(+)PR(+)HER-2(+) (PPP; triple positive). For ALN, the following variables were tested in uni- and multivariate models: age at diagnosis (years), tumour size (mm), tumour grade, ER, PR, HER-2 and the combined steroid receptor and HER-2 status. Likelihood ratio chi(2)-tests were used for univariate analysis and logistic regression for multivariate analysis.

RESULTS: Triple positive tumours had a higher likelihood of being ALN positive than others (56.2% versus 35.7%; P<0.0001). Univariate logistic regression also withheld age, size, grade and HER-2 as predictors of ALN involvement. Final multivariate logistic regression revealed age, size, grade and PPP versus non-PPP to be independent predictors of ALN involvement; the odds ratio (OR) and 95% CI for PPP versus non-PPP tumours was 2.169 (1.490-3.156).

CONCLUSION: Our data provide insight into the natural history of triple positive breast carcinomas. Such tumours are more likely ALN positive than those with another steroid receptor and HER-2 status. How these findings correlate with breast cancer prognosis remains to be investigated.
ISSN: 0167-6806
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Multidisciplinary Breast Clinic Section (-)
Laboratory of Experimental Radiotherapy
Section Woman - Miscellaneous (-)
Laboratory of Experimental Oncology
Division of Gene Technology (-)
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Basic Research in Gynaecology Section (-)
Gynaecological Oncology
Translational Cell & Tissue Research
Surgical Oncology
Screening, Diagnostics and Biomarkers (-)
× corresponding author
# (joint) last author

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