Title: Genetic Variation in the Familial Mediterranean Fever Gene (MEFV) and Risk for Crohn's Disease and Ulcerative Colitis
Authors: Villani, Alexandra-Chloe ×
Lemire, Mathieu
Louis, Edouard
Silverberg, Mark S
Collette, Catherine
Fortin, Genevieve
Nimmo, Elaine R
Renaud, Yannick
Brunet, Sebastien
Libioulle, Cecile
Belaiche, Jacques
Bitton, Alain
Gaudet, Daniel
Cohen, Albert
Langelier, Diane
Rioux, John D
Arnott, Ian D. R
Wild, Gary E
Rutgeerts, Paul
Satsangi, Jack
Vermeire, Severine
Hudson, Thomas J
Franchimont, Denis #
Issue Date: Sep-2009
Publisher: Public library science
Series Title: Plos one vol:4 issue:9 pages:-
Abstract: Background and Aims: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1 beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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