Genetic Variation in the Familial Mediterranean Fever Gene (MEFV) and Risk for Crohn's Disease and Ulcerative Colitis
Villani, Alexandra-Chloe × Lemire, Mathieu Louis, Edouard Silverberg, Mark S Collette, Catherine Fortin, Genevieve Nimmo, Elaine R Renaud, Yannick Brunet, Sebastien Libioulle, Cecile Belaiche, Jacques Bitton, Alain Gaudet, Daniel Cohen, Albert Langelier, Diane Rioux, John D Arnott, Ian D. R Wild, Gary E Rutgeerts, Paul Satsangi, Jack Vermeire, Severine Hudson, Thomas J Franchimont, Denis #
Public library science
Plos one vol:4 issue:9 pages:-
Background and Aims: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1 beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.