Title: Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians
Authors: Bentley, R W ×
Cleynen, Isabelle
Gearry, R B
Barclay, M L
Rutgeerts, Paul
Merriman, T R
Ferrante, Marc
Roberts, R L
Vermeire, Severine #
Issue Date: Sep-2010
Publisher: Nature Pub. Group
Series Title: Genes and Immunity vol:11 issue:6 pages:509-514
Abstract: The transcription factor glioma-associated oncogene homolog 1 (GLI1) has a central function in gastrointestinal tract development and homeostasis. A non-synonymous single-nucleotide polymorphism (SNP) (rs2228226; Q1100E) in GLI1, which impairs GLI1 function in vitro, has been proposed as a risk factor for inflammatory bowel disease (IBD). In this study, we assessed the cumulative evidence for association of GLI1 with IBD. New genotype data for rs2228226 from New Zealand (907 controls, 990 IBD patients) and Belgian Caucasian case-control data sets (312 controls, 1214 IBD patients) were combined with data from the National Institute of Diabetes and Digestive and Kidney Diseases and three previously studied Caucasian case-control data sets. Meta-analysis of rs2228226 did not detect any association with ulcerative colitis (UC) (P = 0.09, odds ratio (OR) = 1.07, 95% confidence interval (CI) = 0.92-1.24), Crohn's disease (CD) (P = 0.29, OR = 1.06, 95% CI = 0.93-1.21) or overall IBD (P = 0.15, OR = 1.05, 95% CI = 0.92-1.19). Our analyses of rs2228226 suggest that GLI1 is not a significant risk factor for IBD in Caucasians. Genes and Immunity (2010) 11, 509-514; doi: 10.1038/gene.2010.15; published online 6 May 2010
ISSN: 1466-4879
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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