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Title: Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects
Authors: Allez, Matthieu ×
Karmiris, Konstantinos
Louis, Edouard
Van Assche, Gert
Ben-Horin, Shomron
Klein, Amir
Van der Woude, Janneke
Baert, Filip
Eliakim, Rami
Katsanos, Konstantinos
Brynskov, Jorn
Steinwurz, Flavio
Danese, Silvio
Vermeire, Severine
Teillaud, Jean-Luc
Lemann, Marc
Chowers, Yehuda #
Issue Date: Oct-2010
Publisher: Elsevier Science BV
Series Title: Journal of Crohns & Colitis vol:4 issue:4 pages:355-366
Abstract: The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways. (C) 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
ISSN: 1873-9946
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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