Title: Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
Authors: Franke, Andre ×
Balschun, Tobias
Sina, Christian
Ellinghaus, David
Haesler, Robert
Mayr, Gabriele
Albrecht, Mario
Wittig, Michael
Buchert, Eva
Nikolaus, Susanna
Gieger, Christian
Wichmann, H. Erich
Sventoraityte, Jurgita
Kupcinskas, Limas
Onnie, Clive M
Gazouli, Maria
Anagnou, Nicholas P
Strachan, David
McArdle, Wendy L
Mathew, Christopher G
Rutgeerts, Paul
Vermeire, Severine
Vatn, Morten H
Krawczak, Michael
Rosenstiel, Philip
Karlsen, Tom H
Schreiber, Stefan #
Issue Date: Apr-2010
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:42 issue:4 pages:292-294
Abstract: We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P-rs7809799 = 8.81 x 10(-11) and P-rs5771069 = 4.21 x 10(-8), respectively).
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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