Title: Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
Authors: Hov, Johannes R ×
Keitel, Verena
Laerdahl, Jon K
Spomer, Lina
Ellinghaus, Eva
ElSharawy, Abdou
Melum, Espen
Boberg, Kirsten M
Manke, Thomas
Balschun, Tobias
Schramm, Christoph
Bergquist, Annika
Weismueller, Tobias
Gotthardt, Daniel
Rust, Christian
Henckaerts, Liesbet
Onnie, Clive M
Weersma, Rinse K
Sterneck, Martina
Teufel, Andreas
Runz, Heiko
Stiehl, Adolf
Ponsioen, Cyriel Y
Wijmenga, Cisca
Vatn, Morten H
Stokkers, Pieter C. F
Vermeire, Severine
Mathew, Christopher G
Beuers, Ulrich
Manns, Michael P
Schreiber, Stefan
Schrumpf, Erik
Haeussinger, Dieter
Franke, Andre
Karlsen, Tom H #
Issue Date: Aug-2010
Publisher: Public Library of Sciene
Series Title: PLoS One vol:5 issue:8 pages:-
Abstract: Background: TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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