Title: Region II of the Haemophilus influenzae type be capsulation locus is involved in serotype-specific polysaccharide synthesis
Authors: Van Eldere, Johan ×
Brophy, L
Loynds, B
Celis, P
Hancock, I
Carman, S
Kroll, J S
Moxon, E R #
Issue Date: Jan-1995
Series Title: Molecular Microbiology vol:15 issue:1 pages:107-18
Abstract: The central (serotype-specific) Region II of the Haemophilus influenzae Type b capsulation locus cap is 8.3 kb long and contains a cluster of four genes. We show that these genes, designated orf1 to orf4, are involved in the biosynthetic steps required for the formation of the Type b capsular polysaccharide and that orf1 probably encodes a CDP-ribitolpyrophosphorylase. We present evidence that growth of polysaccharide chains takes place through the alternating addition of single sugar nucleotides.
ISSN: 0950-382X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Experimental and Clinical Microbiology (-)
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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