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Title: The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-media-enhanced magnetic resonance imaging, tumor differentiation, and vascularization
Authors: Ni, Yicheng ×
Marchal, Guy
Zhang, X
Van Hecke, Paul
Michiels, J
Yu, Jie
Rummeny, E
Lodemann, K P
Baert, A L #
Issue Date: Jun-1993
Series Title: Investigative radiology vol:28 issue:6 pages:520-8
Abstract: OBJECTIVES AND RATIONALE. Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and its possible mechanisms. METHODS. Magnetic resonance imaging was performed in 15 rats with chemically induced hepatocellular carcinoma (HCC) before and after Mn-DPDP injection. Both tumor-liver contrast-to-noise ratio and absolute tumor enhancement were evaluated and compared with the MRI results of a nonspecific contrast agent, gadolinium-DOTA, and correlated with corresponding microangiographic and histologic findings. RESULTS. Mn-DPDP injection led to a persistent positive enhancement in differentiated solid HCCs (22/23) with maximal conspicuity at 24 hours. Undifferentiated HCCs were all delineated by a prompt negative enhancement (20/20) with maximal conspicuity within 30 minutes.
ISSN: 0020-9996
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Theragnostic Laboratory (+)
× corresponding author
# (joint) last author

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