In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin
Gyemant, N Engi, H Schelz, Z Szatmari, I Toth, D Fulop, F Molnar, J de Witte, Peter # ×
British Journal of Cancer vol:103 issue:2 pages:178-185
BACKGROUND: The multidrug resistance (MDR) proteins are present in a majority of human tumours. Their activity is important to understand the chemotherapeutic failure. A search for MDR-reversing compounds was conducted among various Betti-base derivatives of tylosin.