Title: Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor
Authors: Keddie, Neil S
Ye, Yulin
Aslam, Tashfeen
Luyten, Tomas
Bello, Davide
Garnham, Clive
Bultynck, Geert
Galione, Antony
Conway, Stuart J # ×
Issue Date: Jan-2011
Publisher: Royal Society of Chemistry
Series Title: Chemical Communications vol:47 issue:1 pages:242-244
Abstract: The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.
ISSN: 1359-7345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
× corresponding author
# (joint) last author

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