Title: Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives
Authors: Rashad, Adel A ×
El-Sabbagh, Osama I
Baraka, Mohamed M
Ibrahim, Samy M
Pannecouque, Christophe
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Mostafa, Ahmed #
Issue Date: Dec-2010
Publisher: Birkhäuser Boston
Series Title: Medicinal Chemistry Research vol:19 issue:9 pages:1025-1035
Abstract: A new series of N-phenylpyrazoles and dihydroisoxazles was synthesized starting from alpha,beta-unsaturated ketones in basic media using phenyl hydrazine and hydroxylamine HCl, respectively. Antiviral evaluation of the target compounds revealed that the dihydroisoxazole derivatives have promising antiviral activity against hepatitis A virus and herpes simplex virus type 1.
ISSN: 1054-2523
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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