Title: Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication
Authors: Skerlj, Renato ×
Bridger, Gary
McEachern, Ernie
Harwig, Curtis
Smith, Chris
Wilson, Trevor
Veale, Duane
Yee, Helen
Crawford, Jason
Skupinska, Krystyna
Wauthy, Rossana
Yang, Wen
Zhu, Yongbao
Bogucki, David
Di Fluri, Maria
Langille, Jonathon
Huskens, Dana
De Clercq, Erik
Schols, Dominique #
Issue Date: Jan-2011
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:21 issue:1 pages:262-6
Abstract: An early lead from the AMD070 program was optimized and a structure-activity relationship was developed for a novel series of heterocyclic containing compounds. Potent CXCR4 antagonists were identified based on anti-HIV-1 activity and Ca(2+) flux inhibition that displayed good pharmacokinetics in rat and dog.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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