Title: Juvenile xanthogranuloma of the corneoscleral limbus: report of two cases
Authors: De Keyser, Christophe ×
Maudgal, Prabhat
Legius, Eric
Van Ginderdeuren, Rita
Casteels, Ingele #
Issue Date: 2011
Publisher: Aeolus Press
Series Title: Ophthalmic Genetics vol:32 issue:1 pages:54-56
Abstract: Purpose: To report the clinical and histopathologic findings of limbal juvenile xanthogranuloma (JXG) in two children. Methods: Case report. Results: Two children (a 9-month old boy and a 4-year old girl) presented with an enlarging yellowish mass at the corneoscleral limbus. The girl had been diagnosed with neurofibromatosis 1 (NF1). Both lesions underwent simple excision. Histopathologic examination revealed foamy histiocytes within an inflammatory infiltrate with the presence of multiple multinucleated giant cells. In both cases intraoperative subconjunctival steroids and postoperative topical steroids were administered during 1 month. Conclusions: Juvenile xanthogranuloma may rarely present as a mass occurring at the corneoscleral limbus. Therefore it should be considered in the differential diagnosis of any corneoscleral limbal mass lesion, particularly in children. Most are isolated lesions without systemic involvement which are treated by simple excision. But association with NF1 is possible and in that case screening for hematological malignancies is recommended.
ISSN: 1381-6810
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Research Group Ophthalmology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science