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Title: Giant cell rich parosteal osteosarcoma
Authors: Sciot, Raphael ×
Samson, Ignace
Dal Cin, Paola
Lateur, L
Van Damme, Boudewijn
Van den Berghe, Herman
Desmet, Valeer #
Issue Date: Jul-1995
Series Title: Histopathology vol:27 issue:1 pages:51-5
Abstract: A parosteal osteosarcoma of the distal femur with a typical radiographic and macroscopic appearance is reported. On histology the tumour was dominated by large numbers of osteoclast-like giant cells in a fibro-osseous background and islands of immature bone. Most of the neoplastic bone lacked osteoblastic rimming. There was no spatial relationship between the giant cells and areas of haemorrhage. Signs of 'dedifferentiation' were lacking. Cytogenetic a analysis revealed telomeric associations which are frequently found in giant cell tumours of bone. Parosteal osteosarcoma may, on histological appearances, hardly be recognizable as malignant. In addition, unusual changes such as abundant giant cells may be misleading in the absence of clinico-pathological correlation.
ISSN: 0309-0167
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Clinical Genetics Section (-)
Orthopaedics Section (-)
× corresponding author
# (joint) last author

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