Title: Substantial Variation in Transplacental Transfer of Chemotherapeutic Agents in a Mouse Model
Authors: Van Calsteren, Kristel ×
Verbesselt, René
Van Bree, Rieta
Heyns, Lieve
de Bruijn, Ernst
de Hoon, Jan
Amant, Frédéric #
Issue Date: Jan-2011
Publisher: Sage Science Press
Series Title: Reproductive Sciences vol:18 issue:1 pages:57-63
Abstract: Objective: Data on the transplacental transfer of chemotherapeutic agents are lacking. We aimed to measure the maternofetal transfer of cytotoxic drugs in a mouse model. Study design: The transplacental transfer of doxorubicin (9 mg/kg), epirubicin (11 mg/kg), vinblastine (6 mg/kg), carboplatin (50 mg/kg), paclitaxel (10 mg/kg), and cytarabine (100 mg/kg) was tested in a C57/Bl6J mouse model. Ninety minutes after intravenous (IV) drug injection on gestational day 18.5, maternal and fetal blood were collected simultaneously. Plasma drug levels were determined using high performance liquid chromatography or atomic absorption spectrometry. Results: Fetal plasma concentrations of doxorubicin, epirubicin, vinblastine, and cytarabine were 5.1% ± 0.6% (n = 8), 4.8% ± 3.8% (n = 8), 13.8% ± 5.8% (n = 6), and 56.7% ± 22.6% (n = 6) of the maternal concentrations, respectively. Total platinum passed the mouse placenta easily (117.0% ± 38.9%, n = 6). Paclitaxel could not be detected in fetal plasma samples (n = 6). Conclusions: Substantial variations in transplacental transfer were noted among the tested drugs. Current findings contribute to the understanding of reported pregnancy outcomes in humans.
ISSN: 1933-7191
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Pharmacology and Pharmacotherapy
Groep Gezondheid en Welzijn TM K - miscellaneous (-)
Gynaecological Oncology
Department of Oncology - miscellaneous
Organ Systems (+)
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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