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Title: Magnetic resonance imaging, microangiography, and histology in a rat model of primary liver cancer
Authors: Ni, Yicheng
Marchal, Guy ×
Van Damme, Boudewijn
Van Hecke, Paul
Michiels, J
Zhang, X
Yu, Jie
Baert, A L #
Issue Date: Sep-1992
Series Title: Investigative radiology vol:27 issue:9 pages:689-97
Abstract: RATIONALE AND OBJECTIVES. N-nitrosodiethylamine is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in patients than the usual model of tumor implantations. METHODS. Hepatic carcinogenesis was induced in 58 Wistar rats using oral N-nitrosodiethylamine. The rats subsequently were studied by liver magnetic resonance imaging (MRI), postmortem microangiography, and histologic examination. RESULTS. Hepatic tumors developed in 57 rats. A wide variety of the tumors in the degree of vascularization, the type of vessels, the areas of intratumoral secretion and necrosis, and the tumor cell differentiation resulted from the tumor model. The authors were able to assess the contribution of the vascular, extravascular, and cellular components in the final pattern of contrast enhancement in MRI. CONCLUSIONS. The N-nitrosoethylamine model for hepatic tumor induction is simple, and provides a more representative range of tumors for experimental evaluation.
ISSN: 0020-9996
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Translational Cell & Tissue Research
Theragnostic Laboratory (+)
× corresponding author
# (joint) last author

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