Title: Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
Authors: Cai, Weibo ×
Shin, Dong-Woon
Chen, Kai
Gheysens, Olivier
Cao, Qizhen
Wang, Shan X
Gambhir, Sanjiv S
Chen, Xiaoyuan #
Issue Date: Apr-2006
Series Title: Nano letters vol:6 issue:4 pages:669-76
Abstract: We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
ISSN: 1530-6984
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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