Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
Cai, Weibo × Shin, Dong-Woon Chen, Kai Gheysens, Olivier Cao, Qizhen Wang, Shan X Gambhir, Sanjiv S Chen, Xiaoyuan #
Nano letters vol:6 issue:4 pages:669-76
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.