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Title: Comparison of optical coherence tomography, microcomputed tomography, and histology at a three-dimensionally imaged trabecular bone sample
Authors: Kasseck, Christoph ×
Kratz, Marita
Torcasio, Antonia
Gerhardt, Nils C
van Lenthe, Harry
Gambichler, Thilo
Hoffmann, Klaus
Jones, David B
Hofmann, Martin R #
Issue Date: 2010
Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
Series Title: Journal of Biomedical Optics vol:15 issue:4 pages:1-6
Article number: 046019
Abstract: We investigate optical coherence tomography (OCT) as a method for imaging bone. The OCT images are compared directly to those of the standard methods of bone histology and microcomputed tomography (microCT) on a single, fixed human femoral trabecular bone sample. An advantage of OCT over bone histology is its noninvasive nature. OCT also images the lamellar structure of trabeculae at slightly higher contrast than normal bone histology. While microCT visualizes the trabecular framework of the whole sample, OCT can image additionally cells with a penetration depth limited approximately to 1 mm. The most significant advantage of OCT, however, is the absence of toxic effects (no ionizing radiation), i.e., continuous images may be made and individual cell tracking may be performed. The penetration depth of OCT, however, limits its use to small animal models and small bone organ cultures.
URI: 
ISSN: 1083-3668
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomechanics Section
× corresponding author
# (joint) last author

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