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Title: Loop model: mechanism to explain partial gene duplications in segmented dsRNA viruses
Authors: Matthijnssens, Jelle
Rahman, Mustafizur
Van Ranst, Marc # ×
Issue Date: Feb-2006
Series Title: Biochemical and Biophysical Research Communications vol:340 issue:1 pages:140-144
Abstract: Gene rearrangements in a head-to-tail fashion have been described several times for gene segments of the rota-, phytoreo-, and orbiviruses. Several mechanisms have been proposed to explain the occurrence of partial duplications, however, none of these models has been fully satisfactory to explain the occurrence of all the observed duplicated genes. Based on recently available structural data about the lambda3 RNA-dependent-RNA-polymerase of reoviruses, we propose the 'loop model' as a plausible explanation for the occurrence of partial gene duplications in dsRNA viruses.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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