Title: An expeditious route toward pyrazine-containing nucleoside analogues
Authors: Modha, Sachinkumar
Trivedi, Jalpa C
Mehta, Vaibhav P
Ermolatev, Denis
Van der Eycken, Erik # ×
Issue Date: 7-Jan-2011
Publisher: American Chemical Society
Series Title: Journal of Organic Chemistry vol:76 issue:3 pages:846-856
Abstract: An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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