This item still needs to be validated !
Title: Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin
Authors: Descamps, Francis
Van den Steen, Philippe
Martens, Erik
Ballaux, Florence
Geboes, Karel
Opdenakker, Ghislain # ×
Issue Date: May-2003
Publisher: The Federation of American Societies for Experimental Biology
Series Title: FASEB Journal vol:17 issue:8 pages:887-9
Abstract: Genetic, endocrine, and environmental factors contribute to the development of diabetes. Much information has been gathered on the homeostasis mechanisms of glucose regulation by insulin-producing pancreatic beta cells. Here we demonstrate high expression levels of gelatinase B (matrix metalloproteinase-9, MMP-9) by neutrophils in acute pancreatitis and by ductular epithelial cells in chronic pancreatitis. Because gelatinase B processes cytokines and chemokines, we investigated whether and how gelatinase B cleaves insulin. Pure human neutrophil gelatinase B was found to destroy insulin by cleavage at 10 sites. Pancreatic islet and ductular cells are relatively spared in comparison with the complete destruction of acinar cells of the exocrine pancreas in chronic pancreatitis. High expression levels of gelatinase B are maintained in the immediate proximity of insulin-secreting beta cells. Consequently, diabetes may be worsened by enzymatic degradation of insulin by gelatinase B and by the consequent enhancement of the autoimmune process. Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
ISSN: 0892-6638
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Biochemistry Section (Medicine) (-)
Translational Research in GastroIntestinal Disorders
Translational Cell & Tissue Research
Faculty of Pharmaceutical Sciences - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science