Enantioselective biocatalytic reactions on (+/-)-aryl alkyl ketones with native and modified porcine pancreatic lipase
Husain, Mofazzal × Kumar, Vineet Kumar, Rajesh Shakil, Najam A Sharma, Sunil K Prasad, Ashok K Olsen, Carl E Gupta, Rajendra K Malhotra, Sanjay V Van der Eycken, Erik Depass, Anthony L Levon, Kalle Parmar, Virinder S #
Taylor & francis ltd
Biocatalysis and biotransformation vol:28 issue:3 pages:172-184
Porcine pancreatic lipase (PPL), pre-incubated with acetophenone in tetrahydrofuran, fails to recognize ortho- and para acyloxy functions with respect to the nuclear carbonyl group in (+/-)-2,4-diacyloxyphenyl alkyl ketones and produces novel aryl alkyl ketones in moderate-to-highly optically active forms; this result supports the hypothesis on the mechanism of action of PPL in deacylation reactions on peracylated polyphenolics.