Title: Enantioselective biocatalytic reactions on (+/-)-aryl alkyl ketones with native and modified porcine pancreatic lipase
Authors: Husain, Mofazzal ×
Kumar, Vineet
Kumar, Rajesh
Shakil, Najam A
Sharma, Sunil K
Prasad, Ashok K
Olsen, Carl E
Gupta, Rajendra K
Malhotra, Sanjay V
Van der Eycken, Erik
Depass, Anthony L
Levon, Kalle
Parmar, Virinder S #
Issue Date: Jun-2010
Publisher: Taylor & francis ltd
Series Title: Biocatalysis and biotransformation vol:28 issue:3 pages:172-184
Abstract: Porcine pancreatic lipase (PPL), pre-incubated with acetophenone in tetrahydrofuran, fails to recognize ortho- and para acyloxy functions with respect to the nuclear carbonyl group in (+/-)-2,4-diacyloxyphenyl alkyl ketones and produces novel aryl alkyl ketones in moderate-to-highly optically active forms; this result supports the hypothesis on the mechanism of action of PPL in deacylation reactions on peracylated polyphenolics.
ISSN: 1024-2422
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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