Title: Diversity-Oriented Microwave-Assisted Synthesis of the 3-Benzazepine Framework
Authors: Peshkov, Vsevolod A ×
Pereshivko, Olga P
Donets, Pavel Alexandrovich
Mehta, Vaibhav P
Van der Eycken, Erik #
Issue Date: Sep-2010
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:25 pages:4861-4867
Abstract: An efficient diversity-oriented procedure for the two-step synthesis of 3-benzazepines is described. The Cu-I-catalyzed three-component coupling of an aldehyde, an alkyne and an amine (A(3)-coupling) provides the required propargylamines and assures the generation of diversity. The Pd-catalyzed intramolecular acetylene hydroarylation reaction selectively creates the seven-membered 3-benzazepine framework with full control over the ring size and the geometry around the double bond. Microwave irradiation is demonstrated to be highly efficient in promoting both steps.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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