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Title: Ia+ dendritic cells lining the dermo-epidermal junction in bullous skin disorders, associated with the deposition of immune complexes
Authors: Drijkoningen, Maria ×
Peeters, C
van den Oord, Joost
Vanneste, A
Degreef, Hugo
Desmet, Valeer #
Issue Date: Jan-1985
Series Title: Virchows Archiv. A, Pathological anatomy and histopathology vol:406 issue:3 pages:301-7
Abstract: Skin biopsies from 34 patients, presenting with a variety of bullous skin disorders were investigated, using routine light microscopy and immunohistochemistry. In bullous skin diseases characterized by deposition of complement factors (CF) and/or immunoglobulins (Ig), a monolayer of OKIa+1, OKT-6, OKM-1 dendritic cells was found at the dermo-epidermal junction. Retrospectively, these cells were easily recognized on paraffin embedded, H & E stained material. In bullous skin disorders, showing no deposition of CF and/or Ig, this monolayer of dendritic cells was lacking. It is suggested that these OKIa+1, OKT-6, OKM-1 dendritic cells at the dermo-epidermal junction represent some type of antigen presenting cells, not corresponding to Langerhans cells, veiled cells or indeterminate cells.
ISSN: 0174-7398
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartmental Platform Hospital Care
Laboratory of Dermatology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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