Title: Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors
Authors: Elayadi, Hanane ×
Smietana, Michael
Pannecouque, Christophe
Leyssen, Pieter
Neyts, Johan
Vasseur, Jean-Jacques
Lazrek, Hassan B #
Issue Date: Dec-2010
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:20 issue:24 pages:7365-7368
Abstract: Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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