Title: Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy
Authors: Sennlaub, F
Valamanesh, F
Vazquez-Tello, A
El-Asrar, A M
Checchin, D
Brault, S
Gobeil, F
Beauchamp, M H
Mwaikambo, B
Courtois, Y
Geboes, Karel
Varma, D R
Lachapelle, P
Ong, H
Behar-Cohen, F
Chemtob, S #
Issue Date: Jul-2003
Series Title: Circulation vol:108 issue:2 pages:198-204
Abstract: BACKGROUND: Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy. METHODS AND RESULTS: We describe here that COX-2 is induced in retinal astrocytes in human diabetic retinopathy, in the murine and rat model of ischemic proliferative retinopathy in vivo, and in hypoxic astrocytes in vitro. Specific COX-2 but not COX-1 inhibitors prevented intravitreal neovascularization, whereas prostaglandin E2, mainly via its prostaglandin E receptor 3 (EP3), exacerbated neovascularization. COX-2 inhibition induced an upregulation of thrombospondin-1 and its CD36 receptor, consistent with the observed antiangiogenic effects of COX-2 inhibition; EP3 stimulation reversed effects of COX-2 inhibitors on thrombospondin-1 and CD36. CONCLUSIONS: These findings point to an important role for COX-2 in ischemic proliferative retinopathy, as in diabetes.
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
# (joint) last author

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