Title: Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives
Authors: Stevens, Miguel ×
Pollicita, Michela
Pannecouque, Christophe
Verbeken, Eric
Tabarrini, Oriana
Cecchetti, Violetta
Aquaro, Stefano
Perno, Carlo Federico
Fravolini, Arnaldo
De Clercq, Erik
Schols, Dominique
Balzarini, Jan #
Issue Date: Apr-2007
Publisher: American Society for Microbiology (ASM)
Series Title: Antimicrobial Agents and Chemotherapy vol:51 issue:4 pages:1407-1413
Abstract: Two novel 6-desfluoroquinolone derivatives HM-12 and HM-13 were evaluated for their anti-HIV activity in acutely, chronically and latently HIV-1-infected cell cultures and found to behave as potent HIV-1 transcription inhibitors. In order to extend this result in vivo, we developed an artificial hu-SCID mouse model for HIV-1 latency based on SCID mice engrafted with latently HIV-1-infected promyelocytic OM-10.1 cells in which HIV-1 can be reactivated in vivo by the administration of hTNF-alpha. Treating these SCID mice with HM-12 or HM-13 prior to hTNF-alpha stimulation resulted in a pronounced suppressive effect on viral reactivation. Since both quinolone derivatives were able to inhibit the reactivation of HIV-1 from this artificial viral reservoir in vivo, we provide encouraging evidence for the use of quinolones in the control of HIV-1 infections.
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Translational Cell & Tissue Research
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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