Title: Pharmacological Rescue of p53 in Cancer Therapy: Widening the Sensitive Tumor Spectrum by Targeting MDMX
Authors: Marine, Chris # ×
Issue Date: 16-Nov-2010
Publisher: Cell Press
Series Title: Cancer Cell vol:18 issue:5 pages:399-400
Abstract: Targeting p53's main negative regulator MDM2 is a promising strategy for treating cancers that retain wild-type p53. Unfortunately, MDM2 inhibitors are largely ineffective against tumors overexpressing MDMX. In this issue of Cancer Cell, Bernal et al. describe a "stapled" peptide that targets MDMX and suppresses the growth of tumors resistant to MDM2 inhibitors.
ISSN: 1535-6108
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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