Title: Determination of adenosine and inosine in sheep plasma using solid phase extraction followed by liquid chromatography with uv detection
Authors: Chitta, Rajesh ×
Pendela, Murali
Yekkala, Raja
Herijgers, Paul
Hoogmartens, Jos
Adams, Erwin #
Issue Date: 2010
Publisher: M. Dekker
Series Title: Analytical Letters vol:43 issue:14 pages:2267-2274
Abstract: A simple and sensitive liquid chromatography assay following solid phase extraction was developed for simultaneous determination of adenosine and inosine in sheep plasma. The system consisted of a Symmetry C-18 column, a mobile phase composed of acetonitrile, 100 mM sodium dihydrogen phosphate and water, and ultraviolet detection at 254 nm. The method showed good sensitivity (limits of detection for adenosine and inosine were 30 and 50 ng/ml, respectively, in the plasma samples), repeatability, and linearity. The developed method was applied to sheep plasma samples from a study examining the cardio active potential of the combination of adenosine and inosine.
ISSN: 0003-2719
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Experimental Cardiac Surgery (-)
Pharmaceutical Analysis
× corresponding author
# (joint) last author

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