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Title: Localization of metalloporphyrin-induced "specific" enhancement in experimental liver tumors: Comparison of magnetic resonance imaging, microangiographic, and histologic findings
Authors: Ni, Yicheng ×
Marchal, Guy
Yu, Jie
Lukito, Gregorius
Petré, Carine
Wevers, Martine
Baert, Albert
Ebert, Wolfgang
Hilger, Christian-Stephan
Maier, Franz-Karl
Semmler, Wolfhard #
Issue Date: Aug-1995
Publisher: Assoc univ radiologists
Series Title: Academic Radiology vol:2 issue:8 pages:687-699
Abstract: We investigated the tumor specificity of gadolinium mesoporphyrin (Gd-MP) and manganese tetraphenylporphyrin (Mn-TPP) as magnetic resonance (MR) imaging contrast agents. METHODS: Fifteen rats with multiple hepatocellular carcinomas and eight rats with implanted Novikoff hepatomas were given intravenous injections of either Gd-MP or Mn-TPP at 0.05 mmol/kg, which was compared with nonspecific gadopentetate dimeglumine (0.3 mmol/kg). T1-weighted spin-echo images were obtained before and up to 48 hr after injection and compared with corresponding microangiograms and histologic specimens. The relative enhancement of organs and tumors was plotted as a function of time. RESULTS: Initially, both metalloporphyrins behaved as nonspecific agents, similar to gadopentetate dimeglumine, and enhanced the tumor by perfusion and diffusion. However, metalloporphyrins, but not gadopentetate dimeglumine, caused a delayed (> or = 3 hr) enhancement in some compartments of certain lesions. The MR imaging-microangiography-histology matching technique revealed that those compartments were actually nonviable components, including necrosis (n = 10), thrombosis (n = 7), and cystic secretion (n = 3), but not viable tumor tissue. CONCLUSION: Metalloporphyrins did not prove to be tumor specific. However, the observed affinity for nonviable tissue has elicited other potential applications for these agents.
ISSN: 1076-6332
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Mechanical Metallurgy Section (-)
Faculty of Medicine - miscellaneous
Theragnostic Laboratory (+)
× corresponding author
# (joint) last author

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