11th International Congress of the IUPESM. Medical Physics and Biomedical Engineering. World Congress 2009. Micro- and Nanosystems in Active Implants, Biosensors, Date: 2009/09/07 - 2009/09/12, Location: Munich, Germany
Publication date:
2009-01-01
Volume:
25
Pages:
314 -
316
ISSN:
978-3-642-03886-0
Publisher:
Springer Verlag; Berlin, Germany
PROCEEDINGS of the 11th International Congress of the IUPESM. Medical Physics and Biomedical Engineering. World Congress 2009. Micro- and Nanosystems in Active Implants, Biosensors
Author:
Benilova, Iryna
Kuperstein, I ; Broersen, K ; Rousseau, Frederic ; Schymkowitz, Joost ; Bartic, Carmen ; De Strooper, Bart ; Dossel, O ; Schlegel, WC
Keywords:
Science & Technology, Technology, Physical Sciences, Engineering, Biomedical, Physics, Applied, Engineering, Physics, MEA, amyloid, oligomers, synapse, Alzheimer, ALZHEIMERS-DISEASE, PEPTIDE
Abstract:
Microelectrode arrays were used for monitoring the impact of Alzheimer's amyloid oligomers on hippocampal neurons. Micromolar concentrations of Aβ 42 oligomers, but not fibrils, potently inhibited spontaneous electrical activity of the cells; the effect was partially reversible. The significance of the method for Alzheimer's disease research is studied. © 2009 Springer-Verlag.