Title: Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures
Authors: Lebeau, Ilya ×
Andrei, Graciela
Dal Pozzo, Fabiana
Beadle, James R
Hostetler, Karl Y
De Clercq, Erik
van den Oord, Joost
Snoeck, Robert #
Issue Date: Jul-2006
Publisher: Amer soc microbiology
Series Title: Antimicrobial Agents and Chemotherapy vol:50 issue:7 pages:2525-9
Abstract: The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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