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Title: The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target
Authors: Mattheus, Wesley
Masschelein, Joleen
Gao, Ling-Jie
Herdewijn, Piet
Landuyt, Bart
Volckaert, Guido
Lavigne, Rob # ×
Issue Date: Oct-2010
Publisher: Current Biology Ltd.
Series Title: Chemistry & Biology vol:17 issue:10 pages:1067-71
Abstract: BatG is a trans-2-enoyl-ACP reductase, encoded in the kalimantacin/batumin (kal/bat) biosynthesis operon. It is not essential for the production of the kal/bat secondary metabolite. Instead, BatG is an isoform of FabI, conferring full resistance to target bacteria. It also complements FabI in its role in fatty acid biosynthesis. The identification of FabI as the antibacterial target is important to assess clinical potential of the kalimantacin/batumin antibiotics against Staphylococcus aureus.
URI: 
ISSN: 1074-5521
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Medicinal Chemistry (Rega Institute)
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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