Title: Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene
Authors: Thoelen, Inge
Magnusson, Caroline
Tågerud, Sven
Polacek, Charlotta
Lindberg, Michael
Van Ranst, Marc # ×
Issue Date: Sep-2001
Series Title: Biochemical and Biophysical Research Communications vol:287 issue:1 pages:216-222
Abstract: The human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) is a transmembrane glycoprotein which belongs to the immunoglobulin superfamily. We describe alternative splicing of the HCAR-gene and the existence of three exon-skipping splice variants in addition to the originally identified seven exon-encompassing mRNA transcript. Expression of the splice variants theoretically results in truncated proteins, possibly leading to impaired viral binding and/or the occurrence of soluble viral receptors due to the absence of the transmembranous region. Consequently, this could markedly influence the efficacy of an adenovirus subgroup C-mediated gene therapy.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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