Title: Additional Value of PET-CT in Staging of Clinical Stage IIB and III Breast Cancer
Authors: Segaert, Isabelle ×
Mottaghy, Felix
Ceyssens, Sarah
De Wever, Walter
Stroobants, Sigrid
Van Ongeval, Chantal
Van Limbergen, Erik
Wildiers, Hans
Paridaens, Robert
Vergote, Ignace
Christiaens, Marie-Rose
Neven, Patrick #
Issue Date: Nov-2010
Publisher: Blackwell Science
Series Title: The Breast Journal vol:16 issue:6 pages:617-624
Abstract: To evaluate retrospectively the accuracy of integrated PET/CT, against PET, CT, or conventional staging in breast cancer. Seventy consecutive biopsy proven clinical stage IIB and III breast cancer patients were included. Descriptive statistics of integrated PET/CT for the primary tumor, nodal status and metastasis detection were compared to PET, CT with contrast, and conventional staging (biochemistry, chest X-ray, liver ultrasound, and bone scintigraphy). Sensitivity of PET/CT for primary tumor and nodal status was 97.1% and 62.5%, respectively. Specificity and negative predictive value for nodal status were 100% and 66.6%, respectively. The values for conventional staging for nodal involvement were 100% and 85.7% with a sensitivity of 87.5%. PET/CT showed metastatic disease in seven women despite normal conventional staging. PET/CT is able to visualize most clinical stage IIB and III primary breast cancers. PET/CT is superior to conventional staging for detecting internal mammary chain nodes and metastatic disease, but not for axillary staging. Future studies will have to test whether therapy adjustment based on PET/CT has the potential to improve survival.
ISSN: 1075-122X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Laboratory of Experimental Radiotherapy
Laboratory of Experimental Oncology
Multidisciplinary Breast Clinic Section (-)
Surgical Oncology
× corresponding author
# (joint) last author

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