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Title: Binding of von Willebrand Factor to Collagen and Glycoprotein Ib alpha, But Not to Glycoprotein IIb/IIIa, Contributes to Ischemic Stroke in Mice-Brief Report
Authors: De Meyer, Simon ×
Schwarz, Tobias
Deckmyn, Hans
Denis, Cécile V
Nieswandt, Bernhard
Stoll, Guido
Vanhoorelbeke, Karen
Kleinschnitz, Christoph #
Issue Date: Oct-2010
Publisher: Lippincott williams & wilkins
Series Title: Arteriosclerosis thrombosis and vascular biology vol:30 issue:10 pages:1949-1951
Abstract: OBJECTIVE: To unravel crucial von Willebrand factor (VWF) interactions that are detrimental in stroke development. METHODS AND RESULTS: VWF(-/-) mice received gene transfer to express mutants of VWF defective either in binding to fibrillar collagen, glycoprotein (GP)Ibα or GPIIb/IIIa, and underwent 60 minutes of transient middle cerebral artery occlusion. In VWF(-/-) mice reconstituted with VWF mutants defective in binding to collagen or GPIbα, protection against stroke was sustained, whereas VWF lacking the GPIIb/IIIa binding site restored full susceptibility similar to normal VWF. CONCLUSIONS: VWF-collagen and VWF-GPIbα (but not VWF-GPIIb/IIIa) interactions are instrumental in thrombus formation after transient middle cerebral artery occlusion, and their inhibition could be a promising target for stroke treatment.
URI: 
ISSN: 1079-5642
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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